Chemistry:Lu AA-33810

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Short description: Chemical compound
Lu AA-33810
Lu AA33810.svg
Clinical data
Other namesLu AA-33810
ATC code
  • None
Identifiers
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC19H25N3O2S3
Molar mass423.61 g·mol−1
3D model (JSmol)
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Lu AA-33810 is a drug developed by Lundbeck, which acts as a potent and highly selective antagonist for the Neuropeptide Y receptor Y5, with a Ki of 1.5nM and around 3300x selectivity over the related Y1, Y2 and Y4 receptors. In animal studies it produced anorectic, antidepressant and anxiolytic effects, and further research is now being conducted into its possible medical application in the treatment of eating disorders.[1]

References

  1. "The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 (N-([trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl)-methanesulfonamide) exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity". The Journal of Pharmacology and Experimental Therapeutics 328 (3): 900–11. March 2009. doi:10.1124/jpet.108.144634. PMID 19098165.