Chemistry:MC3138
From HandWiki
MC3138 is a drug which acts as a sirtuin-5 (SIRT5) activator. It has potential applications in the treatment of pancreatic cancer, as well as basic research into the function of the SIRT5 enzyme complex.[1][2][3]
References
- ↑ "Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression". Gastroenterology 161 (5): 1584–1600. November 2021. doi:10.1053/j.gastro.2021.06.045. PMID 34245764.
- ↑ "SIRT5 Activation and Inorganic Phosphate Binding Reduce Cancer Cell Vitality by Modulating Autophagy/Mitophagy and ROS". Antioxidants 12 (8): 1635. August 2023. doi:10.3390/antiox12081635. PMID 37627630.
- ↑ "Transcription factor EP300 targets SIRT5 to promote autophagy of nucleus pulposus cells and attenuate intervertebral disc degeneration". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1872 (4). April 2025. doi:10.1016/j.bbamcr.2025.119933. PMID 40096894.
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