Chemistry:MC3482

From HandWiki

MC3482 is a drug which acts as a sirtuin-5 (SIRT5) inhibitor. It has antiinflammatory effects and is used for research into the function of the SIRT5 enzyme complex.[1][2][3]

References

  1. ↑ "SIRT5 regulation of ammonia-induced autophagy and mitophagy". Autophagy 11 (2): 253–270. 2015. doi:10.1080/15548627.2015.1009778. PMID 25700560. 
  2. ↑ "SIRT5 Inhibition Induces Brown Fat-Like Phenotype in 3T3-L1 Preadipocytes". Cells 10 (5): 1126. May 2021. doi:10.3390/cells10051126. PMID 34066961. 
  3. ↑ "The Sirtuin 5 Inhibitor MC3482 Ameliorates Microglia‑induced Neuroinflammation Following Ischaemic Stroke by Upregulating the Succinylation Level of Annexin-A1". Journal of Neuroimmune Pharmacology 19 (1). May 2024. doi:10.1007/s11481-024-10117-x. PMID 38717643. 



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