Chemistry:MDL-811

From HandWiki

MDL-811 is a drug which acts as a sirtuin-6 (SIRT6) activator. It has antiinflammatory effects and shows neuroprotective effects in animal models of stroke and heart attack.[1][2][3][4]

References

  1. ↑ "Small-molecule activating SIRT6 elicits therapeutic effects and synergistically promotes anti-tumor activity of vitamin D3 in colorectal cancer". Theranostics 10 (13): 5845–5864. 2020. doi:10.7150/thno.44043. PMID 32483423. 
  2. ↑ "A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis". Acta Pharmaceutica Sinica. B 11 (3): 708–726. March 2021. doi:10.1016/j.apsb.2020.11.002. PMID 33777677. 
  3. ↑ "SIRT6 in Vascular Diseases, from Bench to Bedside". Aging and Disease 13 (4): 1015–1029. July 2022. doi:10.14336/AD.2021.1204. PMID 35855341. 
  4. ↑ "Sirtuin 6 mitigates thoracic aortic aneurysm progression via maintenance of mitochondria homeostasis in vascular smooth muscle cells". Acta Pharmacologica Sinica. September 2025. doi:10.1038/s41401-025-01628-1. PMID 40897853. 



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