Chemistry:MES207
From HandWiki
MES207 is a drug used in scientific research which acts as a potent and selective antagonist for the neuropeptide FF receptor NPFF1, with 17x selectivity over the closely related receptor NPFF2. It prevented opioid-induced hyperalgesia in animal models.[1][2]
References
- ↑ "Nonpeptide small molecule agonist and antagonist original leads for neuropeptide FF1 and FF2 receptors". Journal of Medicinal Chemistry 57 (21): 8903–8927. November 2014. doi:10.1021/jm500989n. PMID 25268943.
- ↑ "Bioanalytical method development and validation of MES207, a neuropeptide FF receptor antagonist, and its application in preclinical pharmacokinetics". Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 1134-1135. December 2019. doi:10.1016/j.jchromb.2019.121875. PMID 31790916.
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