Chemistry:MK6892

From HandWiki

MK6892 is an experimental drug which acts as a potent and selective agonist for the Hydroxycarboxylic acid receptor 2 (GPR109A). It has been investigated for lowering blood lipid levels and potential applications in the treatment of colon cancer.[1][2][3][4]

References

  1. ↑ "Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate". Journal of Medicinal Chemistry 53 (6): 2666–2670. March 2010. doi:10.1021/jm100022r. PMID 20184326. 
  2. ↑ "Structural insights into the human niacin receptor HCA2-Gi signalling complex". Nature Communications 14 (1). March 2023. doi:10.1038/s41467-023-37177-6. PMID 36973264. Bibcode: 2023NatCo..14.1692Y. 
  3. ↑ "Taking SCFAs produced by Lactobacillus reuteri orally reshapes gut microbiota and elicits antitumor responses". Journal of Nanobiotechnology 22 (1). May 2024. doi:10.1186/s12951-024-02506-4. PMID 38735933. 
  4. ↑ "Insights into the Activation Mechanism of HCA1, HCA2, and HCA3". Journal of Medicinal Chemistry 68 (4): 4527–4539. February 2025. doi:10.1021/acs.jmedchem.4c02567. PMID 39936872. 



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