Chemistry:ML148
From HandWiki
ML148 is a drug which acts as a reasonably potent and selective inhibitor of the enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH), with an IC50 of 56 nM. It increases levels of prostaglandin E2 and stimulates tissue regeneration. It was one of the earliest selective 15-PGDH inhibitors developed, and is now mainly significant as a lead compound which was used to develop more potent derivatives such as HW201877, but is still used in research as its simple chemical structure and straightforward synthesis makes it a cost-effective alternative to more complex compounds.[1][2][3]
References
- ↑ "Potent and selective inhibitors of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (HPGD)". Probe Reports from the NIH Molecular Libraries Program. Bethesda: National Center for Biotechnology Information. 2010.
- ↑ "High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships". PLOS ONE 5 (11). November 2010. doi:10.1371/journal.pone.0013719. PMID 21072165. Bibcode: 2010PLoSO...513719N.
- ↑ "Discovery of two small molecule inhibitors, ML387 and ML388, of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase". Probe Reports from the NIH Molecular Libraries Program. Bethesda: National Center for Biotechnology Information. 2010.
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