Chemistry:Macroketone
From HandWiki
Chemical structure of (4E,6S,7S,8S,9E)-7-hydroxy-8-methoxy-4,6-dimethylcyclotetradeca-4,9-dien-1-one, a macroketone used in the synthesis of migrastatin analogs
Macroketones are macrocyclic compounds that contain a ketone functional group. Macroketones form the central rings systems of some synthetic polyketide antibiotics.[1][2]
References
- ↑ "Synthesis of Novel Macrolactam and Macroketone Analogues of Migrastatin from D-Glucal and Comparison with Macrolactone and Acyclic Analogues: A Dorrigocin A Congener Is a Potent Inhibitor of Gastric Cancer Cell Migration". European Journal of Organic Chemistry 2008 (11): 1953–1958. 2008. doi:10.1002/ejoc.200701192.
- ↑ PDB: 3LNA; "Migrastatin analogues target fascin to block tumour metastasis". Nature 464 (7291): 1062–6. April 2010. doi:10.1038/nature08978. PMID 20393565. Bibcode: 2010Natur.464.1062C.
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