Chemistry:Methylliberine
Methylliberine is an isolate of coffee beans, tea, cola nuts, guarana, cocoa, and yerba mate.[1] It is structurally related to Liberine.
Pharmacology
Pharmacodynamics
Based on its structural similarity to caffeine and theacrine methylliberine is widely believed to be an adenosine receptor antagonist, although as of 2023 no scientific studies have been done to confirm this action.[2] There is no evidence that methylliberine augments dopamine receptors in a way that is distinct from caffeine, contrary to claims made by the manufacturer.[3][4]
Pharmacokinetics
Methylliberine has a short half-life of only 1.5 hours compared to the 5- to 7-hour half-life of caffeine.[5] An interaction study showed concomitant administration of both caffeine and methylliberine increases the half-life of caffeine by about 2 fold.[5] This is likely due to inhibition of the CYP1A2 enzyme.[5]
References
- ↑ "Minor alkaloids in caffeine-containing beverages". Deutsche Lebensmittel-Rundschau 96 (11): 363–368. 2000. http://www.cabdirect.org/abstracts/20003008257.html;jsessionid=9F32FB941DCD1B7597BDCAE41579154E. Retrieved 2013-10-16.
- ↑ VanDusseldorp, Trisha A.; Stratton, Matthew T.; Bailly, Alyssa R.; Holmes, Alyssa J.; Alesi, Michaela G.; Feito, Yuri; Mangine, Gerald T.; Hester, Garrett M. et al. (28 February 2020). "Safety of Short-Term Supplementation with Methylliberine (Dynamine®) Alone and in Combination with TeaCrine® in Young Adults". Nutrients 12 (3): 654. doi:10.3390/nu12030654. PMID 32121218.
- ↑ Garrett, B. E.; Holtzman, S. G. (January 1994). "D1 and D2 dopamine receptor antagonists block caffeine-induced stimulation of locomotor activity in rats". Pharmacology, Biochemistry, and Behavior 47 (1): 89–94. doi:10.1016/0091-3057(94)90115-5. ISSN 0091-3057. PMID 7906891.
- ↑ VanDusseldorp, Trisha A.; Stratton, Matthew T.; Bailly, Alyssa R.; Holmes, Alyssa J.; Alesi, Michaela G.; Feito, Yuri; Mangine, Gerald T.; Hester, Garrett M. et al. (2020-02-28). "Safety of Short-Term Supplementation with Methylliberine (Dynamine®) Alone and in Combination with TeaCrine® in Young Adults". Nutrients 12 (3): 654. doi:10.3390/nu12030654. ISSN 2072-6643. PMID 32121218.
- ↑ 5.0 5.1 5.2 Mondal, Goutam; Wang, Yan-Hong; Yates, Ryan; Bloomer, Richard; Butawan, Matthew (9 August 2022). "Caffeine and Methylliberine: A Human Pharmacokinetic Interaction Study: Original Research". Journal of Exercise and Nutrition 5 (3). doi:10.53520/jen2022.103124.
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