Chemistry:NK012
From HandWiki
NK012 is a 'nanodevice' formulation of SN-38 (an irinotecan metabolite). NK012 is an SN-38-releasing polymeric micelle constructed by covalently attaching SN-38 to the block copolymer PEG-PGlu, followed by self-assembly of amphiphilic block copolymers in aqueous media.[1] [2]
It has completed phase II clinical trials for triple-negative breast cancer and relapsed small cell lung cancer.[3] In 2016, Nippon Kayaku received orphan drug designation for NK012 from the US FDA.[4] This means that if it is approved in the United States, Nippon Kayaku will be entitled to 7 years of market exclusivity. This is intended to incentivize future development, but does not mean the drug has been approved.[citation needed]
See also
- Nanomedicine
- Targeted drug delivery
References
- ↑ "NCI Drug Dictionary" (in en). 2011-02-02. https://www.cancer.gov/publications/dictionaries/cancer-drug.
- ↑ Sumitomo (2008). "Novel SN-38–Incorporated Polymeric Micelle, NK012, Strongly Suppresses Renal Cancer Progression". http://cancerres.aacrjournals.org/content/68/6/1631.abstract.
- ↑ "Search of: NK012 - List Results - ClinicalTrials.gov" (in en). https://www.clinicaltrials.gov/ct2/results?term=NK012.
- ↑ Nippon Kayaku Announces FDA Orphan Drug Designation to New Polymeric micelle Anti-Cancer Drug NK012 for Small Cell Lung Cancer. (2016). Evaluategroup.com. Retrieved 24 November 2017, from http://www.evaluategroup.com/Universal/View.aspx?type=Story&id=644017
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