Chemistry:Napabucasin

From HandWiki

Napabucasin (BBI-608) is a natural product found in the inner bark of the tree Handroanthus impetiginosus, that acts as an inhibitor of the transcription factor protein STAT3. It has potential applications in the treatment of cancer, acting as a stemness inhibitor.[1][2][3][4][5]

See also

References

  1. ↑ "Napabucasin and Related Heterocycle-Fused Naphthoquinones as STAT3 Inhibitors with Antiproliferative Activity against Cancer Cells". Journal of Natural Products 81 (7): 1636–1644. July 2018. doi:10.1021/acs.jnatprod.8b00247. PMID 30003778. Bibcode: 2018JNAtP..81.1636L. 
  2. ↑ "STAT3: An Emerging Therapeutic Target for Hepatocellular Carcinoma". Cancers 11 (11): 1646. October 2019. doi:10.3390/cancers11111646. PMID 31731457. 
  3. ↑ "Naphthoquinone Derivatives Isolated from Plants: Recent Advances in Biological Activity". Mini Reviews in Medicinal Chemistry 20 (19): 2019–2035. 2020. doi:10.2174/1389557520666200818212020. PMID 32811411. 
  4. ↑ "The Anticancer Effect of Napabucasin (BBI608), a Natural Naphthoquinone". Molecules 28 (15): 5678. July 2023. doi:10.3390/molecules28155678. PMID 37570646. 
  5. ↑ "Recent progress of napabucasin as privileged scaffold in the discovery of anticancer agents". European Journal of Medicinal Chemistry 305. January 2026. doi:10.1016/j.ejmech.2026.118559. PMID 41494471. 



Retrieved from "https://handwiki.org/wiki/index.php?title=Chemistry:Napabucasin&oldid=4308922"