Chemistry:Nisinic acid
From HandWiki
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| Preferred IUPAC name
(6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosa-6,9,12,15,18,21-hexaenoic acid | |
| Other names
all-cis-6,9,12,15,18,21-tetracosahexaenoic acid
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| Identifiers | |
3D model (JSmol)
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PubChem CID
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| Properties | |
| C24H36O2 | |
| Molar mass | 356.550 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Tracking categories (test):
Nisinic acid is a very long chain polyunsaturated omega-3 fatty acid, similar to docosahexaenoic acid (DHA). The lipid name is 24:6 (n-3) and the chemical name is all-cis-6,9,12,15,18,21-tetracosahexaenoic acid. It is not well studied, but polyunsaturated fatty acids even longer than DHA, nisinic acid included, may hold scientific promise.[1] It has biological activity and is involved in the formation of DHA, but the mechanisms are still under research.[2][3][4][5]
References
- ↑ Vyssotski, M. (2011). "Nisinic acid, 24: 6n-3, and other methylene-interrupted very long chain polyunsaturated fatty acids". in Paige L. Gilmore. Lipids: Categories, Biological Functions and Metabolism, Nutrition and Health. Nova Science Publishers. pp. 199–216. ISBN 978-1-61668-464-8. https://www.callaghaninnovation.govt.nz/nisinic-acid-24-6n-3-and-other-methylene-interrupted-very-long-chain-polyunsaturated-fatty-acids. Retrieved 2017-03-22.
- ↑ Gotoh, Naohiro; Nagao, Koji; Ishida, Hiroki; Nakamitsu, Kazusa; Yoshinaga, Kazuaki; Nagai, Toshiharu; Beppu, Fumiaki; Yoshinaga-Kiriake, Aya et al. (2018). "Metabolism of Natural Highly Unsaturated Fatty Acid, Tetracosahexaenoic Acid (24:6n-3), in C57BL/KsJ-db/db Mice". Journal of Oleo Science 67 (12): 1597–1607. doi:10.5650/jos.ess18167. https://www.jstage.jst.go.jp/article/jos/67/12/67_ess18167/_article.
- ↑ Metherel, Adam H.; Bazinet, Richard P. (2019-10-01). "Updates to the n-3 polyunsaturated fatty acid biosynthesis pathway: DHA synthesis rates, tetracosahexaenoic acid and (minimal) retroconversion". Progress in Lipid Research 76. doi:10.1016/j.plipres.2019.101008. ISSN 0163-7827. https://www.sciencedirect.com/science/article/abs/pii/S0163782719300517.
- ↑ Metherel, Adam H.; Domenichiello, Anthony F.; Kitson, Alex P.; Lin, Yu-Hong; Bazinet, Richard P. (2017-02-01). "Serum n-3 Tetracosapentaenoic Acid and Tetracosahexaenoic Acid Increase Following Higher Dietary α-Linolenic Acid but not Docosahexaenoic Acid" (in en). Lipids 52 (2): 167–172. doi:10.1007/s11745-016-4223-0. ISSN 1558-9307. https://link.springer.com/article/10.1007/s11745-016-4223-0.
- ↑ Rotarescu, Ruxandra D.; Rezaei, Kimia; Mutch, David M.; Metherel, Adam H. (2022-10-01). "Increases in plasma n-3 tetracosapentaenoic acid and tetracosahexaenoic acid following 12 weeks of EPA, but not DHA, supplementation in women and men". Prostaglandins, Leukotrienes and Essential Fatty Acids 185. doi:10.1016/j.plefa.2022.102494. ISSN 0952-3278. https://www.sciencedirect.com/science/article/pii/S0952327822001065.
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