Chemistry:PA-915
From HandWiki
PA-915 is a drug used in scientific research which acts as a selective antagonist of the pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1). In animal studies it has been found to prevent the development of allodynia and shows analgesic effects against neuropathic pain,[1] and also shows antidepressant effects.[2]
See also
- BAY 2686013
References
- ↑ "Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain". European Journal of Medicinal Chemistry 186. January 2020. doi:10.1016/j.ejmech.2019.111902. PMID 31771828.
- ↑ "Rapid and long-lasting antidepressant-like effects of the pituitary adenylate cyclase-activating polypeptide receptor antagonist PA-915 in chronic stress mouse models". Molecular Psychiatry. September 2025. doi:10.1038/s41380-025-03209-4. PMID 40908362.
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