Chemistry:PER977
From HandWiki
PER977 is a small molecule drug that is under investigation as a potential antidote for multiple anticoagulants, including factor Xa inhibitors, direct thrombin inhibitors, low molecular weight heparins and fondaparinux. It is being developed by Perosphere.[1] In a study with rats treated with rivaroxaban, apixaban and dabigatran, PER977 decreased bleeding by over 90%.[2]
References
- ↑ Dolgin E (March 2013). "Antidotes edge closer to reversing effects of new blood thinners". Nature Medicine 19 (3): 251. doi:10.1038/nm0313-251. PMID 23467222.
- ↑ "Small Molecule Antidote for Anticoagulants". Circulation 126 (21 Suppl): A11395. November 2012. http://circ.ahajournals.org/cgi/content/meeting_abstract/126/21_MeetingAbstracts/A11395.
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