Chemistry:Paradoxin
From HandWiki
Paradoxin (PDX) is a presynaptic neurotoxic phospholipase found in the venom of the inland taipan (Oxyuranus microlepidotus), an extremely venomous species of snake native to Australia.[1]
Structure
It is similar in structure to another neurotoxin named taipoxin. However they differ in how they are neurotoxic. It is a heterotrimer and composed of three subunits.[2][3]
Toxicity
Relatively little is known about paradoxin including its neuromuscular activity.[1] It is known that paradoxin blocks nerve impulses in the synapses by disrupting and blocking neuromuscular transmission.[4]
References
- ↑ 1.0 1.1 Hodgson, Wayne C.; Dal Belo, Cháriston André; Rowan, Edward G. (2007-04-01). "The neuromuscular activity of paradoxin: A presynaptic neurotoxin from the venom of the inland taipan (Oxyuranus microlepidotus)". Neuropharmacology 52 (5): 1229–1236. doi:10.1016/j.neuropharm.2007.01.002. ISSN 0028-3908. PMID 17313963. https://www.sciencedirect.com/science/article/pii/S0028390807000056.
- ↑ Harrison, Julian A.; Aquilina, J. Andrew (2016-03-15). "Insights into the subunit arrangement and diversity of paradoxin and taipoxin". Toxicon 112: 45–50. doi:10.1016/j.toxicon.2016.01.054. ISSN 0041-0101. PMID 26827926. Bibcode: 2016Txcn..112...45H. https://www.sciencedirect.com/science/article/pii/S0041010116300058.
- ↑ Jackson, Timothy; Sunagar, Kartik; Undheim, Eivind; Koludarov, Ivan; Chan, Angelo; Sanders, Kate; Ali, Syed; Hendrikx, Iwan et al. (18 December 2013). "Venom Down Under: Dynamic Evolution of Australian Elapid Snake Toxins". Toxins 5 (12): 2621–2655. doi:10.3390/toxins5122621. PMID 24351719. PMC 3873703. https://www.researchgate.net/publication/259386545.
- ↑ Kuruppu, Sanjaya; Chaisakul, Janeyuth; Smith, A. Ian; Hodgson, Wayne C. (2014-04-01). "Inhibition of Presynaptic Neurotoxins in Taipan Venom by Suramin" (in en). Neurotoxicity Research 25 (3): 305–310. doi:10.1007/s12640-013-9426-z. ISSN 1476-3524. PMID 24129771. https://doi.org/10.1007/s12640-013-9426-z.
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