Chemistry:Photopharmacology
Photopharmacology, an emerging approach in medicine, involves activating and deactivating photoswitchable molecules with light for target drug delivery. Clinicians use the energy of light to change the shape and chemical properties of a drug, resulting in different biological activity.[1] This is done to ultimately achieve control of when and where drugs are active in a reversible manner, and to prevent side effects and exposure to the environment of antibiotics.[2] Switching drugs "on" and "off" is achieved by introducing photoswitches such as azobenzene, spiropyran or diarylethene into the drug. Photopharmalogical drugs with a photoswitch have two different states, which light can toggle between. Since both states have a different structure, the activity of the drug is different, hence the "on" and "off" state of the drug.[3][4] An example is photostatin, which is an inhibitor that can be switched on and off in vivo to optically control microtubule dynamics.[5][6][need quotation to verify]
See also
References
- ↑ "Szymanski Lab". http://www.szymanski-lab.nl/Photopharmacology.html.
- ↑ "Photopharmacology offers light-controlled drugs and therapies". https://optics.org/news/10/6/29.
- ↑ Velema, Willem A.; Szymanski, Wiktor; Feringa, Ben L. (12 February 2014). "Photopharmacology: Beyond Proof of Principle". J. Am. Chem. Soc. 136 (6): 2178–2191. doi:10.1021/ja413063e. PMID 24456115. https://www.rug.nl/research/portal/en/publications/photopharmacology(d6714f52-c2c8-4e48-b345-238e98bcc776).html.
- ↑ Broichhagen, Johannes (2015). "A Roadmap to Success in Photopharmacology". Accounts of Chemical Research 48 (7): 1947–1960. doi:10.1021/acs.accounts.5b00129. PMID 26103428.
- ↑ Borowiak, Malgorzata; Nahaboo, Wallis; Reynders, Martin; Nekolla, Katharina; Jalinot, Pierre; Hasserodt, Jens; Rehberg, Markus; Delattre, Marie et al. (2015-07-16). "Photoswitchable Inhibitors of Microtubule Dynamics Optically Control Mitosis and Cell Death" (in en). Cell 162 (2): 403–411. doi:10.1016/j.cell.2015.06.049. ISSN 0092-8674. PMID 26165941.
- ↑ "Colourful chemotherapy". The Economist. July 11, 2015. ISSN 0013-0613. https://www.economist.com/news/science-and-technology/21657352-optical-switching-may-abolish-side-effects-cancer-drugs-colourful.
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