Chemistry:Proctosedyl
Proctosedyl is the brand name for a family of two products with identical active ingredients designed to treat a variety of proctological disorders. One is a topical ointment, the other a rectal suppository. In the United Kingdom both products are contract manufactured by Patheon Limited on behalf of the Sanofi-Aventis group.[1][2] Manufacture and distribution is provided by Sanofi Aventis subsidiaries[3] Hoechst and Hoechst Marion Roussel in other territories worldwide.[4]
Application
Both the yellowish-white, translucent, greasy ointment[1] and the smooth, off-white suppositories[2] are formulated for the relief of chronic pruritus ani (otherwise known anal itching or anusitis)[1][2][5] and the treatment of pain, irritation, discharge and itching associated with haemorrhoids (otherwise known as piles).[1][2][5] However both products are also used to provide pain relief in the treatment of anal fissure,[6][7][8] for patients undergoing haemorrhoidectomy, (pre and post-operative),[8] in the relief of post-partum (otherwise known as post-natal) haemorrhoidal conditions,[8][9] and in the treatment of non-infective proctitis.[8]
Active ingredients
Both preparations contain:
- Cinchocaine hydrochloride at a concentration of 5 mg/g[1][2] to provide anaesthesia, analgesia and to act as a spasmolytic.[8]
- Hydrocortisone at a concentration of 5 mg/g.[1][2] to provide antipruritic and anti-inflammatory relief[8]
Preparations in some territories may also contain:
- Framycetin sulfate at a concentration of 10 mg/g[4] as an antibacterial agent.[10]
- Aesculin at a concentration of 10 mg/g[4] for its retardant effect on Escherichia coli (otherwise known as E. Coli).[11]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 "Patient Information Leaflets Online: Proctosedyl Ointment: PL 04425/0207". Archived on 2012-02-20. Error: If you specify
|archivedate=, you must also specify|archiveurl=. http://xpil.medicines.org.uk/ViewPil.aspx?DocID=8301. Retrieved 2009-01-21. - ↑ 2.0 2.1 2.2 2.3 2.4 2.5 "Patient Information Leaflets Online: Proctosedyl Suppositories: PL 04425/0208". http://xpil.medicines.org.uk/ViewPil.aspx?DocID=8302. Retrieved 2009-01-21.
- ↑ "Sanofi Aventis: Hoechst Home Page". Archived on 2009-12-19. Error: If you specify
|archivedate=, you must also specify|archiveurl=. http://www.sanofi-aventis.de/live/de/de/layout.jsp?scat=AC603939-733B-4C0D-8AAB-0F6E3BF9B2B7. Retrieved 2009-01-22. - ↑ 4.0 4.1 4.2 "The South African Medical Formulary: C05A Antihaemorrhoidals for topical use". http://web.uct.ac.za/depts/mmi/jmoodie/c05html.html. Retrieved 2009-01-22.
- ↑ 5.0 5.1 "NetDoctor: Proctosedyl ointment/suppositories". http://www.netdoctor.co.uk/medicines/100002157.html. Retrieved 2009-01-21.
- ↑ "Randomized, double-blind trial comparing topical nitroglycerine with xylocaine and Proctosedyl in idiopathic chronic anal fissure". Indian Journal of Gastroenterology 23 (3): 91–3. 2004. PMID 15250565.
- ↑ "A general practitioner study to evaluate the efficacy of 'Proctosedyl' ointment in the treatment of acute fissure-in-ano". The British Journal of Clinical Practice 24 (7): 289–91. July 1970. PMID 4919315.
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 "Medsafe: Information for Health Professionals: Proctosedyl". Archived from the original on October 22, 2008. https://web.archive.org/web/20081022155652/http://www.medsafe.govt.nz/profs/Datasheet/p/Proctosedylointsupp.htm. Retrieved 2009-01-21.
- ↑ "[Our experience in using the preparation Proctosedyl from the Roussel firm in pregnant women with hemorrhoids]" (in Bulgarian). Akusherstvo I Ginekologii͡a 32 (3): 71. 1993. PMID 8037333.
- ↑ Larsen PO (September 1992). "[The Danish fund for basic research--a new cigar-box]" (in Danish). Ugeskrift for Laeger 154 (39): 2657. PMID 1413190.
- ↑ "Effects of esculin and esculetin on the survival of Escherichia coli O157 in human faecal slurries, continuous-flow simulations of the rumen and colon and in calves". The British Journal of Nutrition 91 (5): 749–55. May 2004. doi:10.1079/BJN20041101. PMID 15137927.
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