Chemistry:Proteomimetic
From HandWiki
Proteomimetics are molecules that mimic certain protein characteristics such as shape, binding properties or enzymatic activity.[1] While conceptually linked to peptidomimetics which mimic short peptide sequences or secondary structures, proteomimetics recapitulate tertiary structures. This can involve the mimicry of entire protein domains[2] or fragments thereof.[3] Proteomimetic approaches can range from entirely abiotic scaffolds[2] to specific main chain and side chain-modifications.[4][5]
References
- ↑ "Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns". Nat. Chem. 12 (4): 331–337. April 2020. doi:10.1038/s41557-020-0420-9. PMID 32029906. Bibcode: 2020NatCh..12..331H.
- ↑ 2.0 2.1 "Designing cooperatively folded abiotic uni- and multimolecular helix bundles". Nat. Chem. 10 (1): 51–57. January 2018. doi:10.1038/nchem.2854. PMID 29256508. Bibcode: 2018NatCh..10...51D. https://hal.archives-ouvertes.fr/hal-01848987/file/manuscript_for%20HAL.pdf.
- ↑ "Covalent Proteomimetic Inhibitor of the Bacterial FtsQB Divisome Complex". J. Am. Chem. Soc. 144 (33): 15303–15313. August 2022. doi:10.1021/jacs.2c06304. PMID 32029906. Bibcode: 2022JAChS.14415303P.
- ↑ "Heterogeneous-backbone foldamer mimics of a computationally designed, disulfide-rich miniprotein". ChemBioChem 20 (4): 103–110. November 2018. doi:10.1002/cbic.201800558. PMID 6314896.
- ↑ "In situ cyclization of native proteins: Structure-based design of a bicyclic enzyme". Angew. Chem. Int. Ed. 57 (35): 11164–11170. August 2018. doi:10.1002/anie.201804506. PMID 6120448. Bibcode: 2018ACIE...5711164P.
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