Chemistry:Psora-4
From HandWiki
Psora-4 is an experimental drug that acts as a selective inhibitor of the Kv1.3 potassium channel. It has immunomodulatory effects, suppressing the proliferation of memory T cells, but increases neural progenitor cell proliferation and has lifespan-extending effects in animal studies.[1][2][3][4][5][6][7][8]
References
- ↑ "Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators". Molecular Pharmacology 65 (6): 1364–1374. June 2004. doi:10.1124/mol.65.6.1364. PMID 15155830.
- ↑ "Selective blockage of Kv1.3 and Kv3.1 channels increases neural progenitor cell proliferation". Journal of Neurochemistry 99 (2): 426–437. October 2006. doi:10.1111/j.1471-4159.2006.03967.x. PMID 17029597.
- ↑ "Voltage-gated potassium channel Kv1.3 blocker as a potential treatment for rat anti-glomerular basement membrane glomerulonephritis". American Journal of Physiology. Renal Physiology 299 (6): F1258–F1269. December 2010. doi:10.1152/ajprenal.00374.2010. PMID 20810612.
- ↑ "Kv1.3 blockers ameliorate allergic contact dermatitis by preferentially suppressing effector memory T cells in a rat model". Clinical and Experimental Dermatology 38 (8): 897–903. December 2013. doi:10.1111/ced.12097. PMID 24252082.
- ↑ "Psora-4, a Kv1.3 Blocker, Enhances Differentiation and Maturation in Neural Progenitor Cells". CNS Neuroscience & Therapeutics 21 (7): 558–567. July 2015. doi:10.1111/cns.12402. PMID 25976092.
- ↑ "Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling". Developmental Cell 47 (1): 67–79.e5. October 2018. doi:10.1016/j.devcel.2018.09.001. PMID 30269951.
- ↑ "A small-molecule Psora-4 acts as a caloric restriction mimetic to promote longevity in C. elegans". GeroScience 44 (2): 1029–1046. April 2022. doi:10.1007/s11357-021-00374-6. PMID 33988831.
- ↑ "KCNE4-dependent modulation of Kv1.3 pharmacology". Biochemical Pharmacology 226. August 2024. doi:10.1016/j.bcp.2024.116368. PMID 38880360.
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