Chemistry:Purmorphamine
From HandWiki
Short description: Chemical compound
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| Formula | C31H32N6O2 |
| Molar mass | 520.637 g·mol−1 |
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Purmorphamine was the first small-molecule agonist developed for the protein Smoothened, a key part of the hedgehog signaling pathway, which is involved in bone growth, cardiovascular regeneration and brain development as well as having a number of other functions in the body. Purmorphamine has been shown to induce osteogenesis in bone tissue as well as influencing growth and differentiation of neurons in the brain.[1][2][3][4][5][6] [7]
References
- ↑ "A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells". Journal of the American Chemical Society 124 (49): 14520–1. December 2002. doi:10.1021/ja0283908. PMID 12465946.
- ↑ "Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway". Chemistry & Biology 11 (9): 1229–38. September 2004. doi:10.1016/j.chembiol.2004.06.010. PMID 15380183.
- ↑ "Purmorphamine activates the Hedgehog pathway by targeting Smoothened". Nature Chemical Biology 2 (1): 29–30. January 2006. doi:10.1038/nchembio753. PMID 16408088.
- ↑ "Identification of osteogenic purmorphamine derivatives". Molecules and Cells 26 (4): 380–6. October 2008. PMID 18695357.
- ↑ "Small-molecule modulators of the Sonic Hedgehog signaling pathway". Molecular BioSystems 6 (1): 44–54. January 2010. doi:10.1039/b910196a. PMID 20024066.
- ↑ "Osteoinductive small molecules: growth factor alternatives for bone tissue engineering". Current Pharmaceutical Design 19 (19): 3420–8. 2013. doi:10.2174/1381612811319190008. PMID 23432678.
- ↑ "Preconditioning potential of purmorphamine: a hedgehog activator against ischaemic reperfusion injury in ovariectomised rat heart". Perfusion 33 (3): 209–218. April 2018. doi:10.1177/0267659117732401. PMID 29065787.
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