Chemistry:Queuosine
Queuosine is a modified nucleoside that is present in certain tRNAs in bacteria and eukaryotes.[1][2] It contains the nucleobase queuine. Originally identified in E. coli, queuosine was found to occupy the first anticodon position of tRNAs for histidine, aspartic acid, asparagine and tyrosine.[3] The first anticodon position pairs with the third "wobble" position in codons, and queuosine improves accuracy of translation compared to guanosine.[4][5][6] Synthesis of queuosine begins with GTP. In bacteria, three structurally unrelated classes of riboswitch are known to regulate genes that are involved in the synthesis or transport of pre-queuosine1, a precursor to queuosine: PreQ1-I riboswitches, PreQ1-II riboswitches and PreQ1-III riboswitches.
Queuosine biosynthesis genes have also been found on phage genomes and may be involved in protection from genome degradation by the host.[7][8]
References
- ↑ "Biosynthesis of the 7-deazaguanosine hypermodified nucleosides of transfer RNA". Bioorganic Chemistry 31 (1): 24–43. February 2003. doi:10.1016/S0045-2068(02)00513-8. PMID 12697167.
- ↑ "Queuosine modification of tRNA: a case for convergent evolution". Molecular Genetics and Metabolism 74 (1–2): 147–159. 2001. doi:10.1006/mgme.2001.3216. PMID 11592812.
- ↑ "Possible anticodon sequences of tRNA His, tRNA Asm, and tRNA Asp from Escherichia coli B. Universal presence of nucleoside Q in the first postion of the anticondons of these transfer ribonucleic acids". Biochemistry 11 (2): 301–308. January 1972. doi:10.1021/bi00752a024. PMID 4550561.
- ↑ "Wild-type tRNATyrG reads the TMV RNA stop codon, but Q base-modified tRNATyrQ does not". Nature 294 (5837): 188–190. November 1981. doi:10.1038/294188a0. PMID 29451243. Bibcode: 1981Natur.294..188B.
- ↑ "Queuosine modification of the wobble base in tRNAHis influences 'in vivo' decoding properties". The EMBO Journal 4 (3): 823–827. March 1985. doi:10.1002/j.1460-2075.1985.tb03704.x. PMID 2988936.
- ↑ "Improvement of reading frame maintenance is a common function for several tRNA modifications". The EMBO Journal 20 (17): 4863–4873. September 2001. doi:10.1093/emboj/20.17.4863. PMID 11532950.
- ↑ "Comparative Genomics of Bacteriophage of the Genus Seuratvirus". Genome Biology and Evolution 10 (1): 72–76. January 2018. doi:10.1063/5.0085058.7. PMID 29272407.
- ↑ "Genome annotation and intraviral interactome for the Streptococcus pneumoniae virulent phage Dp-1". Journal of Bacteriology 193 (2): 551–562. January 2011. doi:10.1128/JB.01117-10. PMID 21097633.
Further reading
- "Synthesis of the transfer-RNA nucleoside queuosine by using a chiral allyl azide intermediate". Angewandte Chemie 46 (13): 2325–2327. 2007. doi:10.1002/anie.200604579. PMID 17310487. Bibcode: 2007ACIE...46.2325K.
External links
- Wikigenes: Queuosine
- Human Metabolome Database: Queuosine (HMDB11596)
 |  |
