Chemistry:Relmapirazin

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Relmapirazin (MB-102) is an investigational fluorescent tracer that is exclusively excreted renally and is used to measure glomerular filtration rate of the kidneys.[1][2][3][4][5][6][7]

Using plasma sampling, relmapirazin has been shown to have the same properties and accuracy as iohexol for determining glomerular filtration rate in human subjects of varying kidney function.[8] Furthermore, transdermal optical detection of the change in concentration of intravenously injected relmapirazin has been used to estimate glomerular filtration rate with excellent accuracy in human subjects of varying kidney function and skin color.[9]

References

  1. ↑ Dorshow, Richard B.; Shieh, Jeng-Jong; Debreczeny, Martin P. (17 March 2023). "Clinical results from a pilot multi-center study using a novel fluorescent tracer agent for renal function measurement". Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIV. p. 19. doi:10.1117/12.2648541. ISBN 978-1-5106-5901-8. 
  2. ↑ Orieux, Arthur; Samson, Chloé; Pieroni, Laurence; Drouin, Sarah; Dang Van, Simon; Migeon, Tiffany; Frere, Perrine; Brunet, Dorothée et al. (5 June 2023). "Pulmonary hypertension without heart failure causes cardiorenal syndrome in a porcine model" (in en). Scientific Reports 13 (1): 9130. doi:10.1038/s41598-023-36124-1. ISSN 2045-2322. PMID 37277538. Bibcode: 2023NatSR..13.9130O. 
  3. ↑ Jang, Soo M.; Shieh, Jeng-Jong; Riley, Ivan R.; Dorshow, Richard B.; Mueller, Bruce A. (July 2023). "Adsorption and Clearance of the Novel Fluorescent Tracer Agent MB-102 During Continuous Renal Replacement Therapy: In Vitro Results". ASAIO Journal 69 (7): 702–707. doi:10.1097/MAT.0000000000001943. ISSN 1058-2916. PMID 37071749. 
  4. ↑ Rosner, Mitchell H.; Sprangers, Ben; Sandhu, Geeta; Malyszko, Jolanta (November 2022). "Glomerular Filtration Rate Measurement and Chemotherapy Dosing". Seminars in Nephrology 42 (6). doi:10.1016/j.semnephrol.2023.151340. PMID 37086497. 
  5. ↑ McMahon, Blaithin A.; Rosner, Mitchell H. (February 2020). "GFR Measurement and Chemotherapy Dosing in Patients with Kidney Disease and Cancer". Kidney360 1 (2): 141–150. doi:10.34067/KID.0000952019. PMID 35372903. 
  6. ↑ Schneider, Antoine G.; Molitoris, Bruce A. (December 2020). "Real-time glomerular filtration rate: improving sensitivity, accuracy and prognostic value in acute kidney injury". Current Opinion in Critical Care 26 (6): 549–555. doi:10.1097/MCC.0000000000000770. PMID 33002974. 
  7. ↑ Dorshow, Richard B.; Johnson, James R.; Shieh, Jeng-Jong; Riley, I. Rochelle; Rogers, Thomas E.; Pino, Christopher J.; Johnston, Kimberly A.; Tang, Peter et al. (July 2023). "Transdermal Detection of MB-102 and Correlation to Meropenem Pharmacokinetics During Continuous Renal Replacement Therapy: In Vivo Results". ASAIO Journal 69 (7): 708–715. doi:10.1097/MAT.0000000000001945. PMID 37097973. 
  8. ↑ Dorshow, Richard B.; Debreczeny, Martin P.; Goldstein, Stuart L.; Shieh, Jen Jen (October 2024). "Clinical validation of the novel fluorescent glomerular filtration rate tracer agent relmapirazin (MB-102)". Kidney International 106 (4): 679–687. doi:10.1016/j.kint.2024.06.012. PMID 38964736. 
  9. ↑ Dorshow, Richard B.; Debreczeny, Martin P.; Goldstein, Stuart L. (February 7, 2025). "GFR Measurement Using Transdermal Detection Methodology". Journal of the American Society of Nephrology 36 (8): 1592–1602. doi:10.1681/ASN.0000000639. PMID 39918882. 



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