Chemistry:S-(2-Aminoethyl)isothiuronium bromide hydrobromide
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isothiuronium_bromide_hydrobromide.svg)
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| Names | |
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| IUPAC name
2-aminoethyl carbamimidothioate;dihydrobromide
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| Other names
beta-Aminoethylisothiuronium bromide; beta-Aminoethyl isothiourea; 2-(2-Aminoethyl)-2-thiopseudourea dihydrobromide; AET; AI3-23427; Antirad; Antiradon; Ixecur; Pseudourea, (2-aminoethyl)-2-thio-, dihydrobromide; S-(2-Aminoaethyl)isothiuronium dibromid; S-(2-Aminoethyl)isothiuronium dibromide; S-(2-Aminoethyl)pseudothiourea dihydrobromide; S-2-Aminoethylisothiouronium bromide hydrobromide; Surrectan;
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3D model (JSmol)
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| Properties | |
| C3H11Br2N3S | |
| Molar mass | 281.015 g/mol |
| Hazards | |
| GHS pictograms | 
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| GHS Signal word | Warning |
| H302, H315, H319, H335 | |
| P261, P264, P264+265Script error: No such module "Preview warning".Category:GHS errors, P270, P271, P280, P301+317Script error: No such module "Preview warning".Category:GHS errors, P302+352, P304+340, P305+351+338, P319Script error: No such module "Preview warning".Category:GHS errors, P321, P330, P332+317Script error: No such module "Preview warning".Category:GHS errors, P337+317Script error: No such module "Preview warning".Category:GHS errors, P362+364Script error: No such module "Preview warning".Category:GHS errors, P403+233, P405, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Tracking categories (test):
S-(2-Aminoethyl)isothiourea dihydrobromide,[2] commonly knwn as AET, is a isothiouronium-group-containing reducing agent with textbook uses as a disulfide reducing agent. Though it does not have a free thiol group (-SH) like 2-mercaptoethanol and dithiothreitol (DTT), it reacts with water to decompose transiently into thiol intermediates that acts on disulfide in a manner to these containing free -SH groups.
Applications
One application of AET is in hematology where red cells are treated with AET to create PNH-like cells.[3]
References
- ↑ "2-(2-Aminoethyl)isothiourea dihydrobromide". Pubchem.ncbi.NLM.nih.gov. https://pubchem.ncbi.nlm.nih.gov/compound/2-_2-Aminoethyl_isothiourea-dihydrobromide#section=Safety-and-Hazards.
- ↑ "2-(2-Aminoethyl)isothiourea dihydrobromide". https://pubchem.ncbi.nlm.nih.gov/compound/2-_2-Aminoethyl_isothiourea-dihydrobromide.
- ↑ Sirchia, G (1969). "In-Vitro Lysis of AET-Treated Normal Red Cells (PNH-like Cells) by Normal and Cirrhotic Sera". British Journal of Haematology 17 (3): 245–249. doi:10.1111/j.1365-2141.1969.tb01369.x. PMID 4979897.
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