Chemistry:S6821
From HandWiki
S6821 is a food additive that acts as a potent and selective antagonist of the bitter taste receptor TAS2R8. It has been approved as a food additive to block the bitter taste of certain active pharmaceutical ingredients, excipients, and nutraceuticals which primarily produce their bitter taste through binding to TAS2R8.[1][2]
See also
- S9632
References
- ↑ "Toxicological evaluation of two novel bitter modifying flavour compounds: 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-hydroxybenzyl)imidazolidine-2,4-dione and 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-hydroxybenzyl)-5,5-dimethylimidazolidine-2,4-dione". Toxicology Reports 3: 310–327. 2016. doi:10.1016/j.toxrep.2016.02.007. PMID 28959552. Bibcode: 2016ToxR....3..310K.
- ↑ "Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists". Journal of Medicinal Chemistry 63 (9): 4957–4977. May 2020. doi:10.1021/acs.jmedchem.0c00388. PMID 32330040.
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