Chemistry:SLU-PP-332
From HandWiki
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| Names | |
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| Preferred IUPAC name
4-hydroxy-N-[(Z)-naphthalen-2-ylmethylideneamino]benzamide | |
| Other names
SLU-PP-332
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| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
PubChem CID
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| Properties | |
| C18H14N2O2 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Tracking categories (test):
SLU-PP-332 is a compound which is a potent but non-selective estrogen related receptor (ERR) agonist, acting most strongly at ERRα with an EC50 of 98 nM. It was found to counteract metabolic syndrome in mice, suggesting a possible role for compounds from this class as medications for the treatment of obesity.[1][2][3][4][5]
References
- ↑ Zhi L, Hudson AR, Van Oeveren CA, Roach SL, Pickens JC, Shen Y, Cuervo C, Valdez LJ, Basinger J, Grant VH, "Small molecule hematopoietic growth factor mimetic compounds that activate hematopoietic growth factor receptors.", US patent 8680150, issued 25 March 2014, assigned to Ligand Pharmaceuticals Inc.
- ↑ "Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity". ACS Chemical Biology 18 (4): 756–771. April 2023. doi:10.1021/acschembio.2c00720. PMID 36988910.
- ↑ "A Synthetic ERR Agonist Alleviates Metabolic Syndrome". The Journal of Pharmacology and Experimental Therapeutics 388 (2): 232–240. September 2023. doi:10.1124/jpet.123.001733. PMID 37739806.
- ↑ "Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney". The American Journal of Pathology 193 (12): 1969–1987. September 2023. doi:10.1016/j.ajpath.2023.07.008. PMID 37717940.
- ↑ "Exercise-mimicking drug sheds weight, boosts muscle activity in mice" (in en). https://news.ufl.edu/2023/09/exercise-mimicking-drug/.
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