Chemistry:SN-011
From HandWiki
SN-011 is an experimental drug which acts as a potent antagonist of the stimulator of interferon genes (STING) protein. It binds with higher affinity to the cyclic dinucleotide binding pocket of STING than the endogenous activator 2'3'-cGAMP, and thereby prevents STING activation. SN-011 has antiinflammatory and antiviral effects by reducing cytokine signalling, and has potential application in numerous disease states in which inflammation plays a role.[1][2][3][4][5][6][7][8]
See also
- H-151
- STING-IN-2
References
- ↑ "STING inhibitors target the cyclic dinucleotide binding pocket". Proceedings of the National Academy of Sciences of the United States of America 118 (24). June 2021. doi:10.1073/pnas.2105465118. PMID 34099558. Bibcode: 2021PNAS..11805465H.
- ↑ "Small molecules targeting cGAS-STING pathway for autoimmune disease". European Journal of Medicinal Chemistry 238. August 2022. doi:10.1016/j.ejmech.2022.114480. PMID 35635952.
- ↑ "Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy". Journal of Medicinal Chemistry 65 (9): 6593–6611. May 2022. doi:10.1021/acs.jmedchem.1c01948. PMID 35452223.
- ↑ "Porphyromonas gingivalis induces an inflammatory response via the cGAS-STING signaling pathway in a periodontitis mouse model". Frontiers in Microbiology 14. 2023. doi:10.3389/fmicb.2023.1183415. PMID 37405166.
- ↑ "Blocking cGAS-STING pathway promotes post-stroke functional recovery in an extended treatment window via facilitating remyelination". Med 5 (6): 622–644.e8. June 2024. doi:10.1016/j.medj.2024.03.018. PMID 38663402.
- ↑ "Therapeutic intervention in neuroinflammation for neovascular ocular diseases through targeting the cGAS-STING-necroptosis pathway". Journal of Neuroinflammation 21 (1): 164. June 2024. doi:10.1186/s12974-024-03155-y. PMID 38918759.
- ↑ "SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responses". bioRxiv. September 2024. doi:10.1101/2024.09.05.611469. PMID 39282446.
- ↑ "The STING antagonist SN-011 ameliorates cisplatin induced acute kidney injury via suppression of STING/NF-κB-mediated inflammation". International Immunopharmacology 146. January 2025. doi:10.1016/j.intimp.2024.113876. PMID 39709905.
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