Chemistry:SRI-42127
From HandWiki
SRI-42127 is an experimental drug which acts to inhibit translocation of the RNA-binding HuR protein. HuR translocation promotes the production of inflammatory cytokines in glial cells, and inhibiting HuR has applications both in the treatment of some forms of cancer, and also neuropathic pain.[1][2][3]
See also
- CMLD-2
- KH-3
References
- ↑ "Targeting the HuR Oncogenic Role with a New Class of Cytoplasmic Dimerization Inhibitors". Cancer Research 81 (8): 2220–2233. April 2021. doi:10.1158/0008-5472.CAN-20-2858. PMID 33602784.
- ↑ "SRI-42127, a novel small molecule inhibitor of the RNA regulator HuR, potently attenuates glial activation in a model of lipopolysaccharide-induced neuroinflammation". Glia 70 (1): 155–172. January 2022. doi:10.1002/glia.24094. PMID 34533864.
- ↑ "Inhibition of the RNA Regulator HuR by SRI-42127 Attenuates Neuropathic Pain After Nerve Injury Through Suppression of Neuroinflammatory Responses". Neurotherapeutics 19 (5): 1649–1661. September 2022. doi:10.1007/s13311-022-01278-9. PMID 35864415.
 |  |
