Chemistry:SW209415
From HandWiki
SW209415 is a drug that acts as a potent inhibitor of the enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH), which increases levels of prostaglandin E2 and promotes tissue regeneration. The (R) or (+) enantiomer is the more active. It has similar potency in vitro to the earlier and better studied related compound SW033291, but its solubility is far higher and its pharmacokinetic properties and bioavailability significantly improved, making it more suitable for development for potential clinical applications. It is being researched for improved healing of broken bones and accelerating recovery from bone marrow transplant.[1][2][3][4]
References
- ↑ "A second-generation 15-PGDH inhibitor promotes bone marrow transplant recovery independently of age, transplant dose and granulocyte colony-stimulating factor support". Haematologica 103 (6): 1054–1064. June 2018. doi:10.3324/haematol.2017.178376. PMID 29472361.
- ↑ "Role of prostaglandin E2 in tissue repair and regeneration". Theranostics 11 (18): 8836–8854. 2021. doi:10.7150/thno.63396. PMID 34522214.
- ↑ "15-PGDH inhibition activates the splenic niche to promote hematopoietic regeneration". JCI Insight 6 (6). March 2021. doi:10.1172/jci.insight.143658. PMID 33600377.
- ↑ "Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system". Nature Communications 14 (1). February 2023. doi:10.1038/s41467-023-36463-7. PMID 36774348. Bibcode: 2023NatCo..14..784H.
 |  |
