Chemistry:SW222746
From HandWiki
SW222746 is a drug which acts as a potent inhibitor of the enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH). It increases levels of prostaglandin E2 and stimulates tissue regeneration, and has good oral bioavailability.[1] It has been researched in animal studies for treatment of muscle wasting in the elderly.[2][3]
References
- ↑ "Orally Bioavailable Quinoxaline Inhibitors of 15-Prostaglandin Dehydrogenase (15-PGDH) Promote Tissue Repair and Regeneration". Journal of Medicinal Chemistry 65 (22): 15327–15343. November 2022. doi:10.1021/acs.jmedchem.2c01299. PMID 36322935.
- ↑ "Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system". Nature Communications 14 (1). February 2023. doi:10.1038/s41467-023-36463-7. PMID 36774348. Bibcode: 2023NatCo..14..784H.
- ↑ "Biocomputational screening of natural compounds targeting 15-hydroxyprostaglandin dehydrogenase to improve skeletal muscle during aging". Molecular Diversity 28 (6): 4425–4439. December 2024. doi:10.1007/s11030-024-10825-9. PMID 38904907.
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