Chemistry:SZC-6
From HandWiki
SZC-6 is a drug from the coumarin family which acts as a sirtuin-3 (SIRT3) activator.[1] It has been used in animal studies to study the potential role of SIRT3 activators in the treatment of complications arising from diabetes.[2][3]
References
- ↑ "SZC-6, a small-molecule activator of SIRT3, attenuates cardiac hypertrophy in mice". Acta Pharmacologica Sinica 44 (3): 546–560. March 2023. doi:10.1038/s41401-022-00966-8. PMID 36042291.
- ↑ "SZC-6 Promotes Diabetic Wound Healing in Mice by Modulating the M1/M2 Macrophage Ratio and Inhibiting the MyD88/NF-χB Pathway". Pharmaceuticals 18 (8): 1143. July 2025. doi:10.3390/ph18081143. PMID 40872534.
- ↑ "Novel coumarin derivative SZC-6 as an allosteric activator of SIRT3 alleviates diabetic kidney disease via the SIRT3-Foxo3a signaling axis". Free Radical Biology & Medicine 240: 29–45. December 2025. doi:10.1016/j.freeradbiomed.2025.08.019. PMID 40803419.
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