Chemistry:Scymnol

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Scymnol, more specifically 5β-scymnol, is a synthetic INCI-listed skin conditioning ingredient.[1][2][3] The molecule is a steroid derivative that behaves as a hydroxyl radical scavenger and is used for the treatment of skin blemishes such as blocked pores and acne.[4][5]

History

The molecule was identified and isolated from shark tissues by Professor Takuo Kosuge, Shizuoka College of Pharmacy, Shizuoka, Japan during the 1980s.[4] Based on usage as a traditional folk remedy, it was hypothesised the ingredient may be effective for the treatment of scalds, blemishes and acne.[6][7]

Traits

Scymnol is a hydroxyl radical scavenger.[5] Scymnol's role in quenching free radicals may play a role in inhibiting acne.[7][8]

References

  1. ↑ "INCI". https://www.personalcarecouncil.org/resources/inci/. 
  2. ↑ "SODIUM SCYMNOL SULFATE - Ingrédient INCI Beauty". https://incibeauty.com/ingredients/7746-sodium-scymnol-sulfate. 
  3. ↑ Dunlop, K.J.; Barnetson, R.S. (February 1995). "A comparative study of isolutrol versus benzoyl peroxide in the treatment of acne". The Australasian Journal of Dermatology 36 (1): 13–15. doi:10.1111/j.1440-0960.1995.tb00917.x. ISSN 0004-8380. PMID 7763215. 
  4. ↑ 4.0 4.1 Chaston, Ian (2017-01-28) (in en). Technological Entrepreneurship: Technology-Driven vs Market-Driven Innovation. Springer. ISBN 978-3-319-45850-2. https://books.google.com/books?id=IfcODgAAQBAJ&dq=%22scymnol%22+%22takuo+kosuge%22&pg=PA251. 
  5. ↑ 5.0 5.1 Macrides et al, A comparison of the hydroxyl radical scavenging properties of the shark bile steroid 5β-scymnol and plant pycnogenols, Biochem Mol Biol Int. 1997 Sep;42(6):1249-60
  6. ↑ Muthusamy, Visalini; Hodges, Lynn D.; Macrides, Theodore A.; Boyle, Glen M.; Piva, Terrence J. (2011). "Effect of Novel Marine Nutraceuticals on IL-1α-Mediated TNF-α Release from UVB-Irradiated Human Melanocyte-Derived Cells". Oxidative Medicine and Cellular Longevity 2011. doi:10.1155/2011/728645. ISSN 1942-0900. PMID 21961050. 
  7. ↑ 7.0 7.1 Guardiola-Griffiths, Cristina (2011-09-01). "Medieval mean girls: on sexual rivalry and the uses of cosmetics in La Celestina" (in English). EHumanista 19: 172–193. https://go.gale.com/ps/i.do?p=AONE&sw=w&issn=15405877&v=2.1&it=r&id=GALE%7CA360475533&sid=googleScholar&linkaccess=abs. 
  8. ↑ Zasloff, M.; Adams, A. P.; Beckerman, B.; Campbell, A.; Han, Z.; Luijten, E.; Meza, I.; Julander, J. et al. (2011). "Squalamine as a broad-spectrum systemic antiviral agent with therapeutic potential". Proceedings of the National Academy of Sciences of the United States of America 108 (38): 15978–15983. doi:10.1073/pnas.1108558108. PMID 21930925. Bibcode: 2011PNAS..10815978Z. 



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