Chemistry:Sodium calcium edetate
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| Trade names | Calcium disodium versenate, others |
| Other names | calcium disodium EDTA, edetate calcium disodium, sodium calcium edetate |
| AHFS/Drugs.com | Monograph |
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| Routes of administration | IV, IM |
| Drug class | chelating agent |
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| Chemical and physical data | |
| Formula | C10H12CaN2Na2O8 |
| Molar mass | 374.270 g·mol−1 |
| 3D model (JSmol) | |
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Sodium calcium edetate (sodium calcium EDTA), also known as edetate calcium disodium among other names, is a medication primarily used to treat lead poisoning,[1] including both short-term and long-term lead poisoning.[2] Sodium calcium edetate came into medical use in the United States in 1953.[2]
Chelation agent
Sodium calcium edetate is in the chelating agent family of medication.[2] It is a salt of edetate with two sodium and one calcium atoms.[3] It works by binding to a number of heavy metals, which renders them almost inert and allows them to leave the body in the urine.[2]
Edetate disodium (Endrate) is a different formulation which does not have the same effects.[2]
Medical use
Sodium calcium edetate's primary use is to treat lead poisoning,[1] for which it is an alternative to succimer.[2] It is given by slow injection into a vein or into a muscle.[1]
For lead encephalopathy sodium calcium edetate is typically used together with dimercaprol.[2] It may also be used to treat plutonium poisoning.[4] It does not appear to be useful for poisoning by tetra-ethyl lead.[2]
Side effects
Common side effects include pain at the site of injection.[2] Other side effects may include kidney problems, diarrhea, fever, muscle pains, and low blood pressure.[1] Benefits when needed in pregnancy are likely greater than the risks.[2]
History
Sodium calcium edetate came into medical use in the United States in 1953.[2] It is on the World Health Organization's List of Essential Medicines.[5]
References
- ↑ 1.0 1.1 1.2 1.3 WHO Model Formulary 2008. World Health Organization. 2009. pp. 59, 62, 65. ISBN 9789241547659.
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 "Edetate Calcium Disodium". The American Society of Health-System Pharmacists. https://www.drugs.com/monograph/edetate-calcium-disodium.html.
- ↑ (in en) Pharmaceutical Chemistry. I. Pragati Books Pvt. Ltd.. 2008. p. 16.11. ISBN 9788185790121. https://books.google.com/books?id=ZkoJsQIhDWkC&pg=SA16-PA11.
- ↑ (in en) Antidotes: Principles and Clinical Applications. CRC Press. 2003. p. 47. ISBN 9780203485071. https://books.google.com/books?id=Ux0-AAAAIAAJ&pg=PA47.
- ↑ Organization, World Health (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva,CH: World Health Organization. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
External links
- "Sodium calcium edetate". U.S. National Institutes of Health. https://druginfo.nlm.nih.gov/drugportal/name/sodium%20calcium%20edetate.
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