Chemistry:Streptothricin
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Streptothricins are a group of antibiotics in the aminoglycoside class.[1] The first antibiotic in the group was isolated from Streptomyces lavendulae in 1942.[2] It was later determined to be a mixture of closely related compounds, and is now known as nourseothricin. Although initial interest was positive because it appeared to be the first broad-spectrum antibiotic, meaning it was effective against both Gram-positive and Gram-negative bacteria, it never found clinical use due to toxicity.[3] However, because of the increasing need for new antibiotics due to resistance to existing antibiotics, there is a current interest in developing new drugs based on the chemical scaffold of the streptothricins.[1][4][5]
References
- ↑ 1.0 1.1 Franck, Ezabelle; Crofts, Terence S. (2024). "History of the streptothricin antibiotics and evidence for the neglect of the streptothricin resistome". npj Antimicrobials and Resistance 2 (1): 3. doi:10.1038/s44259-023-00020-5. PMID 39843956.
- ↑ Waksman, S. A. & Woodruff, H. B. (1942). "Streptothricin, a new selective bacteriostatic and bactericidal agent, particularly active against Gram-negative bacteria". Proc. Soc. Exp. Biol. Med. 49 (2): 207–210. doi:10.3181/00379727-49-13515.
- ↑ STANLEY AR (1946). "Proceedings of Local Branches of the Society of American Bacteriologists". Journal of Bacteriology 52 (3): 399–404. doi:10.1128/JB.52.3.399-404.1946. PMID 21065179.
- ↑ Morgan, Christopher E.; Kang, Yoon-Suk; Green, Alex B.; Smith, Kenneth P.; Dowgiallo, Matthew G.; Miller, Brandon C.; Chiaraviglio, Lucius; Truelson, Katherine A. et al. (2023). "Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome". PLOS Biology 21 (5). doi:10.1371/journal.pbio.3002091. PMID 37192172.
- ↑ "Forgotten Antibiotic From Decades Past Could Be a Superbug Killer". October 30, 2024. https://www.sciencealert.com/forgotten-antibiotic-from-decades-past-could-be-a-superbug-killer.
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