Chemistry:TLR4-IN-C34
From HandWiki
Short description: Chemical compound
 | |
| Identifiers | |
|---|---|
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C17H27NO9 |
| Molar mass | 389.401 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
TLR4-IN-C34 (or C34) is a drug which acts as a potent and selective antagonist of Toll-like receptor 4 (TLR4). In animal studies it blocks TLR4-mediated cytokine release and has antiinflammatory effects.[1][2][3]
See also
- M62812
- Resatorvid
References
- ↑ "Pharmacological inhibition of TLR4/NF-κB with TLR4-IN-C34 attenuated microcystin-leucine arginine toxicity in bovine Sertoli cells". Journal of Applied Toxicology 39 (6): 832–843. June 2019. doi:10.1002/jat.3771. PMID 30671980.
- ↑ "Lactobacillus salivarius BP121 prevents cisplatin‑induced acute kidney injury by inhibition of uremic toxins such as indoxyl sulfate and p‑cresol sulfate via alleviating dysbiosis". International Journal of Molecular Medicine 45 (4): 1130–1140. April 2020. doi:10.3892/ijmm.2020.4495. PMID 32124946.
- ↑ "The Effect of TLR4 Blockade on Some Indicators of Systemic Inflammatory Response to Proteus mirabilis LPS in Rats". Bulletin of Experimental Biology and Medicine 169 (6): 795–797. October 2020. doi:10.1007/s10517-020-04981-9. PMID 33098506.
 |  |
