Chemistry:TLR4-IN-C34

From HandWiki

TLR4-IN-C34 (or C34) is a drug which acts as a potent and selective antagonist of Toll-like receptor 4 (TLR4). In animal studies it blocks TLR4-mediated cytokine release and has antiinflammatory effects.[1][2][3][4][5]

See also

References

  1. ↑ "Pharmacological inhibition of TLR4/NF-κB with TLR4-IN-C34 attenuated microcystin-leucine arginine toxicity in bovine Sertoli cells". Journal of Applied Toxicology 39 (6): 832–843. June 2019. doi:10.1002/jat.3771. PMID 30671980. 
  2. ↑ "Lactobacillus salivarius BP121 prevents cisplatin‑induced acute kidney injury by inhibition of uremic toxins such as indoxyl sulfate and p‑cresol sulfate via alleviating dysbiosis". International Journal of Molecular Medicine 45 (4): 1130–1140. April 2020. doi:10.3892/ijmm.2020.4495. PMID 32124946. 
  3. ↑ "The Effect of TLR4 Blockade on Some Indicators of Systemic Inflammatory Response to Proteus mirabilis LPS in Rats". Bulletin of Experimental Biology and Medicine 169 (6): 795–797. October 2020. doi:10.1007/s10517-020-04981-9. PMID 33098506. 
  4. ↑ "TLR4-IN-C34 Inhibits Lipopolysaccharide-Stimulated Inflammatory Responses via Downregulating TLR4/MyD88/NF-κB/NLRP3 Signaling Pathway and Reducing ROS Generation in BV2 Cells". Inflammation 45 (2): 838–850. April 2022. doi:10.1007/s10753-021-01588-8. PMID 34727285. 
  5. ↑ "TLR4-IN-C34 protects against acute kidney injury via modulating TLR4/MyD88/NF-κb axis, MAPK, and apoptosis". Iranian Journal of Basic Medical Sciences 25 (11): 1334–1340. November 2022. PMID 36474570. 




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