Chemistry:M62812
From HandWiki
Short description: Chemical compound
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| Formula | C13H11N3OS |
| Molar mass | 257.31 g·mol−1 |
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M62812 is a drug which acts as a potent and selective antagonist of toll-like receptor 4 (TLR4). In animal studies it blocks TLR4-mediated cytokine release and has antiinflammatory effects, showing efficacy in animal models of arthritis and septic shock.[1][2]
See also
- TLR4-IN-C34
- Resatorvid
- VGX-1027
References
- ↑ "Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice". European Journal of Pharmacology 569 (3): 237–43. August 2007. doi:10.1016/j.ejphar.2007.05.013. PMID 17588563.
- ↑ "TAP2, a peptide antagonist of Toll-like receptor 4, attenuates pain and cartilage degradation in a monoiodoacetate-induced arthritis rat model". Scientific Reports 10 (1): 17451. October 2020. doi:10.1038/s41598-020-74544-5. PMID 33060735. Bibcode: 2020NatSR..1017451P.
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