Chemistry:Taniborbactam
From HandWiki
Taniborbactam (development code VNRX-5133) is a pharmaceutical drug that acts as a β-lactamase inhibitor.[1] It inhibits the function of bacterial β-lactamases which impart resistance to β-lactam antibiotics. However, unlike other β-lactamase inhibitors that are used as pharmaceuticals, taniborbactam is effective against enzymes of the New Delhi metallo-beta-lactamase 1 group which are the most frequently identified sources of acquired antibiotic resistance worldwide.[2]
Taniborbactam, in combination with cefepime, is in clinical trials for the treatment of bacterial infections, including urinary tract infection and pyelonephritis.[3][4]
References
- ↑ "Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections". Journal of Medicinal Chemistry 63 (6): 2789–2801. March 2020. doi:10.1021/acs.jmedchem.9b01518. PMID 31765155.
- ↑ "NDM-9 resistance to taniborbactam". The Lancet. Infectious Diseases 23 (4): 401–402. April 2023. doi:10.1016/S1473-3099(23)00069-5. PMID 36796395.
- ↑ "Cefepime-Taniborbactam in Complicated Urinary Tract Infection". The New England Journal of Medicine 390 (7): 611–622. February 2024. doi:10.1056/NEJMoa2304748. PMID 38354140.
- ↑ "Cefepime/taniborbactam - VenatoRx Pharmaceuticals". AdisInsight. Springer Nature Switzerland AG. https://adisinsight.springer.com/drugs/800049949.
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