Chemistry:Threshold of toxilogical concern

From HandWiki

The threshold of toxilogical concern (or TTC) is a method for determining the level of exposure to chemicals above which would be considered toxic,[1] in cases where data about such chemicals is scarce or non-existent.[2][3][4][5][6]

The principle of the TTC can be applied to avoiding animal testing using the concept of exposure based waiving (EBW), where, if a threshold of concern in terms of human exposure can be identified from historic toxicology testing data, further animal testing can be waived on the basis of the individual chemical structures and existing toxicology data for the class of chemicals. This principle has been applied to the waiving of complex animal inhalation toxicology testing in particular (Exposure based waiving: the application of the toxicological threshold of concern (TTC) to inhalation exposure for aerosol ingredients in consumer products.[7]

References

  1. ↑ Kroes, R.; Kleiner, J.; Renwick, A. (August 2005). "The threshold of toxicological concern concept in risk assessment". Toxicological Sciences 86 (2): 226–230. doi:10.1093/toxsci/kfi169. ISSN 1096-6080. PMID 15829616. 
  2. ↑ Abstract jhsph.edu
  3. ↑ Threshold of Toxicological Concern American Chemistry
  4. ↑ Serafimova, Rositsa; Coja, Tamara; Kass, George E. N. (2021). "Application of the Threshold of Toxicological Concern (TTC) in Food Safety: Challenges and Opportunities". Frontiers in Toxicology 3. doi:10.3389/ftox.2021.655951. ISSN 2673-3080. PMID 35295160. 
  5. ↑ Development, Office of Research &. "Derivation of New Threshold of Toxicological Concern Values for Exposure via Inhalation for Environmentally-Relevant Chemicals". https://cfpub.epa.gov/si/si_public_record_Report.cfm?dirEntryId=351559&Lab=CCTE. 
  6. ↑ Najjar, Abdulkarim; Ellison, Corie A.; Gregoire, Sebastien; Hewitt, Nicola J. (2023-01-01). "Practical application of the interim internal threshold of toxicological concern (iTTC): a case study based on clinical data" (in en). Archives of Toxicology 97 (1): 155–164. doi:10.1007/s00204-022-03371-6. ISSN 1432-0738. PMID 36149470. Bibcode: 2023ArTox..97..155N. 
  7. ↑ 2009. P Carthew , C Clapp, S Gutsell PMID: 19275927 DOI: 10.1016/j.fct.2009.02.024)




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