Chemistry:Toltrazuril
Toltrazuril is an antiparasitic medication used primarily to treat coccidiosis in animals. Coccidiosis is a parasitic disease caused by coccidia, which are microscopic, spore-forming, single-celled obligate intracellular parasites belonging to the apicomplexan class Conoidasida.[1][2][3]
Mechanism of action
Toltrazuril works by interfering with the protozoa's ability to reproduce. It disrupts the division of the protozoal nucleus and damages the cell membrane of the parasites. This action results in the destruction of the coccidia at all stages of their life cycle.[4]
Use in veterinary medicine
Toltrazuril is widely used in veterinary medicine to treat coccidiosis in various animals, including poultry, pigs, cattle, sheep, and companion animals like dogs and cats. It is often administered as a single dose or in a series of doses depending on the severity of the infection and the species being treated.[5][6]
References
- ↑ "Efficacy of toltrazuril 5 % suspension (Baycox®, Bayer) and diclazuril (Vecoxan®, Janssen-Cilag) in the control of Eimeria spp. in lambs". Parasitology Research 112 (Suppl 1): 163–168. August 2013. doi:10.1007/s00436-013-3440-1. PMID 23756962.
- ↑ "Toltrazuril - referral". European Medicines Agency. https://www.ema.europa.eu/en/medicines/veterinary/referrals/toltrazuril.
- ↑ "Advances in exotic mammal clinical therapeutics.". Journal of Exotic Pet Medicine 23 (1): 39–49. January 2014. doi:10.1053/j.jepm.2013.11.006. "Toltrazuril, a broad-spectrum anticoccidial drug, is effective against both schizont and gamont stages of Eimeria spp.".
- ↑ "Efficacy of toltrazuril in the prevention of coccidiosis in naturally infected lambs on pasture". Acta Veterinaria Scandinavica 27 (1): 124–137. 1986. doi:10.1186/BF03548565. PMID 3751809.
- ↑ "Toltrazuril treatment for acute clinical coccidiosis in hair goat kids: clinical pathological, haematologic and biochemical findings". Medycyna Weterynaryjna 63 (7): 805. January 2007. https://www.researchgate.net/publication/242775899. Retrieved 1 July 2024.
- ↑ "Coccidiosis control with toltrazuril in conjunction with anticoccidial medicated or nonmedicated feed". Avian Diseases 47 (2): 463–9. 2003. doi:10.1637/0005-2086(2003)047[0463:CCWTIC2.0.CO;2]. PMID 12887207.
 |  |
