Chemistry:Tremorine
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Short description: Chemical compound
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| Formula | C12H20N2 |
| Molar mass | 192.306 g·mol−1 |
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Tremorine is a drug which is used in scientific research to produce tremor in animals. This is used for the development of drugs for the treatment of Parkinson's disease, as tremor is a major symptom which is treated by anti-Parkinson's drugs.[1][2][3][4][5] Beta blockers are also effective in counteracting the effects of tremorine.[6]
History
Tremorine was first reported by Everett et al. in 1956-57.[7][8][9][10]
References
- ↑ "Use of tremorine for screening anti-parkinsonian drugs". Nature 183 (4673): 1462–3. May 1959. doi:10.1038/1831462a0. PMID 13657170. Bibcode: 1959Natur.183.1462T.
- ↑ "Tremorine: Its Effect on Amines of the Central Nervous System". Science 141 (3586): 1188–90. September 1963. doi:10.1126/science.141.3586.1188. PMID 14043364. Bibcode: 1963Sci...141.1188F.
- ↑ "Effect of tremorine, oxotremorine and decaborane on brain histamine levels in rats". Pharmacological Research Communications 3 (4): 345–350. 1971. doi:10.1016/0031-6989(71)90005-1.
- ↑ "Further studies on quantification of drug-induced tremor in mice: effects of antitremorgenic agents on tremor frequency". Experimental Neurology 88 (2): 303–15. May 1985. doi:10.1016/0014-4886(85)90193-1. PMID 3987859.
- ↑ "Antiparkinsonian-like effects of Plumbago scandens on tremorine-induced tremors methodology". Pharmacology, Biochemistry, and Behavior 79 (4): 745–9. December 2004. doi:10.1016/j.pbb.2004.10.004. PMID 15582683.
- ↑ "The role of adrenergic mechanism in tremorine-induced tremors in rats: antitremor effect of beta-adrenoceptor antagonists". Indian Journal of Physiology and Pharmacology 30 (4): 307–12. 1986. PMID 2883120.
- ↑ Everett, Guy M. (1956). "Tremor produced by drugs". Nature v. 177(4522), p. 1238. ("In the routine screening of drugs in mice, we have found only ten out of ten thousand compounds which produce sustained tremor. One of these, 1-4 dipyrrolidino-2-butyne, 'Tremorine', in doses of 5–20 mgm./kgm. produces tremor, salivation, meiosis, etc."
- ↑ Everett G.M., Blockus L.E. and Sheppard I.M. (1956). "Tremor induced by tremorine and its antagonism by anti-Parkinson drugs." Science v. 124, p.79.
- ↑ Everett G.M., Blockus L.E., Sheppard I.M. and Toman J.E.P. (1956), Federation Proceedings v. 15, p. 420.
- ↑ Blockus, L. E. and Everett, G. M. (January 1957). "Tremor producing drug 1,4 di-pyrrolidino-2-butyne (Tremorine)", Federation Proceedings v. 16(1), p. 283.
See also
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