Chemistry:Turkesterone
Turkesterone is a naturally occurring phytoecdysteroid, a subclass of ecdysteroids, which are steroidal compounds structurally related to cholesterol. It is predominantly found in numerous plant species.
In plants
Turkesterone is found in diverse plants, including Ajuga turkestanica,[1] various Vitex species,[2][3][4] Triticum aestivum,[5] Cyanotis arachnoidea and Rhaponticum acaule.[6]
Properties
Turkesterone has a polyhydroxylated structure with a cyclopentanoperhydrophenanthrene skeleton, resembling cholesterol-derived steroids.[7]
Turkesterone is under laboratory research to determine if it has anabolic effects through the activation of the phosphoinositide 3-kinase and AKT signaling pathways.[8]
Its pharmacokinetics, bioavailability, and possible effects in humans remain to be determined.
See also
- Ecdysterone
References
- ↑ "The minor ecdysteroids from Ajuga turkestanica". Phytochemical Analysis 26 (5): 293–300. 2015. doi:10.1002/pca.2563. PMID 25953625. Bibcode: 2015PChAn..26..293G. https://hal.sorbonne-universite.fr/hal-01157962/file/Guibout_2015_The_Minor.pdf.
- ↑ "Ecdysteroids from two Brazilian Vitex species". Fitoterapia 72 (3): 215–220. March 2001. doi:10.1016/s0367-326x(00)00304-x. PMID 11295296.
- ↑ "Ecdysteroids of Vitex scabra stem bark". Journal of Natural Products 65 (11): 1690–1692. November 2002. doi:10.1021/np020199o. PMID 12444704. Bibcode: 2002JNAtP..65.1690S.
- ↑ "Ecdysteroids from the Stem Bark of Vitex doniana Sweet (Lamiaceae; ex. Verbenaceae): A Geographically Variable African Medicinal Species". Antibiotics 10 (8): 937. August 2021. doi:10.3390/antibiotics10080937. PMID 34438987.
- ↑ "Naturally Occurring Ecdysteroids in Triticum aestivum L. and Evaluation of Fenarimol as a Potential Inhibitor of Their Biosynthesis in Plants". International Journal of Molecular Sciences 22 (6): 2855. March 2021. doi:10.3390/ijms22062855. PMID 33799719.
- ↑ "Ecdysteroids from the underground parts of Rhaponticum acaule (L.) DC". Phytochemistry 180. December 2020. doi:10.1016/j.phytochem.2020.112530. PMID 33049649. Bibcode: 2020PChem.180k2530Z. https://www.zora.uzh.ch/id/eprint/190733/1/2.PHYTOCHEMISTRY_Rhaponticum_acaule_23.9.20_final.pdf.
- ↑ "Phytoecdysteroids: biological aspects". Phytochemistry 57 (3): 325–339. June 2001. doi:10.1016/S0031-9422(01)00078-4. PMID 11393511. Bibcode: 2001PChem..57..325D.
- ↑ "Ecdysteroids as non-conventional anabolic agent: performance enhancement by ecdysterone supplementation in humans". Archives of Toxicology 93 (7): 1807–1816. July 2019. doi:10.1007/s00204-019-02490-x. PMID 31123801. Bibcode: 2019ArTox..93.1807I.
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