Chemistry:UBCS385
From HandWiki
UBCS385 is a drug which acts as a sirtuin-4 (SIRT4) inhibitor. It also inhibits SIRT2 with around the same affinity, but has reasonable selectivity over SIRT1, SIRT3, SIRT5 and SIRT6. As one of the first ligands developed that inhibits SIRT4 with high potency, UBCS385 is useful for basic research into the structure and function of the sirtuin-4 enzyme complex.[1][2]
References
- ↑ "Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity". Journal of Medicinal Chemistry 67 (3): 1843–1860. February 2024. doi:10.1021/acs.jmedchem.3c01496. PMID 38253001.
- ↑ "Current Trends in Sirtuin Activator and Inhibitor Development". Molecules 29 (5): 1185. March 2024. doi:10.3390/molecules29051185. PMID 38474697.
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