Chemistry:VLX1570
From HandWiki
VLX1570 is a drug used in scientific research which acts as a non selective inhibitor of proteasome deubiquitinases. It has potential applications in the treatment of cancer, though was discontinued in clinical trials due to excessive toxicity.[1][2][3][4]
References
- ↑ "Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly". ACS Chemical Biology 19 (2): 254–265. February 2024. doi:10.1021/acschembio.3c00330. PMID 38198472.
- ↑ "Dienone Compounds: Targets and Pharmacological Responses". Journal of Medicinal Chemistry 63 (24): 15075–15093. December 2020. doi:10.1021/acs.jmedchem.0c00812. PMID 33146523.
- ↑ "Phase 1 study of the protein deubiquitinase inhibitor VLX1570 in patients with relapsed and/or refractory multiple myeloma". Investigational New Drugs 38 (5): 1448–1453. October 2020. doi:10.1007/s10637-020-00915-4. PMID 32125598.
- ↑ "VLX1570 regulates the proliferation and apoptosis of human lung cancer cells through modulating ER stress and the AKT pathway". Journal of Cellular and Molecular Medicine 26 (1): 108–122. January 2022. doi:10.1111/jcmm.17053. PMID 34854221.
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