Chemistry:VVD-214
From HandWiki
VVD-214 (RO7589831) is a drug which acts as an inhibitor of the enzyme WRN helicase. It is being researched for the treatment of microsatellite instability high forms of cancer.[1][2]
References
- ↑ "Identification of VVD-214/RO7589831, a Clinical-Stage, Covalent Allosteric Inhibitor of WRN Helicase for the Treatment of MSI-High Cancers". Journal of Medicinal Chemistry 68 (24): 25912–25938. December 2025. doi:10.1021/acs.jmedchem.5c01805. PMID 40964743.
- ↑ "Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase". Nature 629 (8011): 435–442. May 2024. doi:10.1038/s41586-024-07318-y. PMID 38658751.
 |  |
