Chemistry:Valienamine
From HandWiki
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| Names | |
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| Preferred IUPAC name
(1S,2S,4R,6S)-6-Amino-4-(hydroxymethyl)cyclohex-4-ene-1,2,3-triol | |
| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
PubChem CID
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| Properties | |
| C7H13NO4 | |
| Molar mass | 175.184 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
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Tracking categories (test):
Valienamine is a C-7 aminocyclitol found as a substructure of pseudooligosaccharides such as the antidiabetic drug acarbose[1] and the antibiotic validamycin. It can be found in Actinoplanes species.[2]
It is an intermediate formed by microbial degradation of validamycins.[3]
References
- ↑ Laube, Heiner (March 2002). "Acarbose An Update of Its Therapeutic Use in Diabetes Treatment". Clinical Drug Investigation 22 (3): 141–156. doi:10.2165/00044011-200222030-00001.
- ↑ "Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway". J. Biol. Chem. 277 (25): 22853–62. June 2002. doi:10.1074/jbc.M202375200. PMID 11937512. http://www.jbc.org/cgi/pmidlookup?view=long&pmid=11937512.
- ↑ CID 193758 from PubChem
External links
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