Chemistry:Valiglurax
From HandWiki
Valiglurax (VU0652957) is an experimental drug that is a positive allosteric modulator for the glutamate receptor mGluR4. It was developed as a potential medication for the treatment of Parkinson's disease.[1][2]
References
- ↑ "Discovery of VU2957 (Valiglurax): An mGlu4 Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson's Disease". ACS Medicinal Chemistry Letters 10 (3): 255–260. March 2019. doi:10.1021/acsmedchemlett.8b00426. PMID 30891122.
- ↑ "The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu4 PAM development candidate". Bioorganic & Medicinal Chemistry Letters 29 (2): 342–346. January 2019. doi:10.1016/j.bmcl.2018.10.050. PMID 30503632.
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