Chemistry:Vixarelimab
From HandWiki
| Monoclonal antibody | |
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| Type | ? |
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| Other names | KPL-716; BIIB069; BIIB-069 |
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Vixarelimab (KPL-716) is a fully human monoclonal antibody that works by binding to the oncostatin M receptor β, thus inhibiting both interleukin 31 and oncostatin M. It is developed by Kiniksa Pharmaceuticals for prurigo nodularis.[1][2][3]
References
- ↑ "Vixarelimab" (in en). https://go.drugbank.com/drugs/DB16350.
- ↑ Sofen, Howard; Bissonnette, Robert; Yosipovitch, Gil; Silverberg, Jonathan I.; Tyring, Stephen; Loo, Wei Jing; Zook, Matthew; Lee, Mark et al. (March 2023). "Efficacy and safety of vixarelimab, a human monoclonal oncostatin M receptor β antibody, in moderate-to-severe prurigo nodularis: a randomised, double-blind, placebo-controlled, phase 2a study". eClinicalMedicine 57: 101826. doi:10.1016/j.eclinm.2023.101826. PMID 36816342.
- ↑ Richards, C; Gandhi, R; Botelho, F; Ho, L; Paolini, J (2020). "Oncostatin M Induction of Monocyte Chemoattractant Protein 1 is Inhibited by Anti-oncostatin M Receptor Beta Monoclonal Antibody KPL-716". Acta Dermato Venereologica 100 (14): adv00197. doi:10.2340/00015555-3505. PMID 32374409.
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