Chemistry:Volhard–Erdmann cyclization
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The Volhard–Erdmann cyclization is an organic synthesis of alkyl and aryl thiophenes by cyclization of disodium succinate or other 1,4-difunctional compounds (γ-oxo acids, 1,4-diketones, chloroacetyl-substituted esters) with phosphorus heptasulfide. The reaction is named after Jacob Volhard and Hugo Erdmann.[1] An example is the synthesis of 3-methylthiophene starting from itaconic acid:[2]
References
- ↑ Feldkamp, R. F.; Tullar, B. F. (1954). "3-Methylthiophene". Organic Syntheses 34: 73. http://www.orgsyn.org/orgsyn/pdfs/CV4P0671.pdf.; Collective Volume, 4, pp. 671
- ↑ Volhard, J.; Erdmann, H. (1885). "Synthetische Darstellung von Thiophen". Chemische Berichte 18 (1): 454–455. doi:10.1002/cber.18850180199. https://zenodo.org/record/1425395.
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