Chemistry:Zinc Synergism & Hinokitiol

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Hinokitiol is a Zink Ionophore, low molecular weight natural products which dissolve in the plasma membrane or intracellular membranes of cells and make the membrane permeable to specific ions [1] [2]. Its capability is believed to inhibit viral replication. In brief, as a zinc ionophore, Hinokitiol aids in the transport molecules into cells through a plasma membrane or intracellular membrane, thus increasing the intracellular concentration of the specified molecule (ex. Zinc). Hence, by taking advantage of Zinc’s antiviral properties, in combination with Hinokitiol, Zinc uptake can be accelerated.

  1. David Epel, Victor D.Vacquier, Margaret Peeler, Pam Miller, Chris Patton, Sea Urchin Gametes in the Teaching Laboratory: Good Experiments and Good Experiences, Methods in Cell Biology Volume 74, 2004, Pages 797-823 [1]
  2. Ionophores. Source [2]. Retrieved July 2020

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