Company:Sapio Sciences

Sapio Sciences LLC

File:Sapio Sciences LLC Logo.png
Founded	2004 (2004)
Headquarters	Baltimore, MD , United States
Products	Laboratory Management software
Website	www.sapiosciences.com

Sapio Sciences is a software vendor that develops and markets the Exemplar software. The Exemplar software encompasses Laboratory Information Management, Electronic Laboratory Notebook, molecular diagnostics, biomarker discovery and data management.

Corporate history

Sapio Sciences was founded in 2004 to develop software tools to address the growing genotyping need for tools to assist in analyzing genetics data, particularly in relation to Genome Wide Association Studies. Sapio's Exemplar Analytics software grew to incorporate over 50 different algorithms. Sapio was subsequently approached by customers to develop a Laboratory Information Management System (LIMS). This led to the development of Exemplar LIMS in June 2007 with several extensions since then. The company targets highly regulated environments such as part 11, GLP and CLIA laboratories.

Products

Exemplar was introduced in 2007 as a LIMS and electronic laboratory notebook product. The software was subsequently expanded to perform additional tasks.

Workflow and data tracking features were introduced in 2008 to allow the software to be used for Scientific Data Management (SDMS). Statistics have also be implemented to perform detailed analysis of scientific data within the same environment.

Electronic lab notebook

The original Exemplar Workflow Engine was optimised for tracking well defined and repeatable lab processes such as in clinical lab settings and these features are still retained in later software packages. In 2015 Sapio introduced the Lab Execution System that expanded on the previous ELN with features for recording ad hoc experiments as opposed to well defined process tracking. It uses a drag and drop interface optimised for rote, repeatable and well defined lab processes. Experimental templates can also be preserved and re-used. The notebook can be used to record, track and search structured and unstructured data.

Notebooks can be shared multiple users who can work on the same workbook simultaneously and be e-signed to ensure proper record keeping for patent protection. Instrument data can be imported as can spreadsheet data, images, etc.

Biomarker discovery

Sapio extended its software with features for biomarker discovery including features for managing clinical study data, treatment groups data, subject data, sample data and assay data from diverse assays such as Immunohistochemistry, Western Blot, PCR, etc. Basic data mining and statistical analysis tools are included for tasks such as data normalization, logistic regression, ANOVA and genetic algorithms.

Molecular diagnostics

Sapio introduced the Exemplar Dx LIMS product for molecular diagnostic companies that is optimised to handle diagnostic test request and results. In addition to sample management and protocol tracking, it emphasises kit and instrument integration with Dx platforms such as Qiagen and Beckman Coulter. Physicians can be presented a web interface for test ordering, or test requests can be imported using the HL7 format. Assay data is then managed in Exemplar and the Dx companies custom algorithms can be implemented to analyze the data and produce the diagnostic report automatically. This report, once electronically signed off, is then delivered via the web, secure fax, HL7 or secure email to the requesting physician.

Product architecture

Exemplar is an n-tier product that offers fully web based clients that run with no software installation on the client machine. Multiple databases are supported for data storage including MySQL and Oracle.