Medicine:Cytoprotection
Cytoprotection is a process by which chemical compounds provide protection to cells against harmful agents.[1]
Gastric cytoprotectant
A gastric cytoprotectant is any medication that combats ulcers not by reducing gastric acid but by increasing mucosal protection.[2] Examples of gastric cytoprotective agents include prostaglandins which protect the stomach mucosa against injury by increasing gastric mucus secretion. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the synthesis of prostaglandins and thereby make the stomach more susceptible to injury.[3] Gastric cytoprotective drugs include carbenoxolone, deglycyrrhizinised liquorice, sucralfate (aluminium hydroxide and sulphated sucrose), misoprostol (a prostaglandin analogue), bismuth chelate (tri-potassium di-citrato bismuthate) and zinc L-carnosine.
References
- ↑ "MeSH Heading: Cytoprotection". Medical Subject Headings. United States National Library of Medicine. https://www.nlm.nih.gov/cgi/mesh/2009/MB_cgi?mode=&term=Cytoprotection.
- ↑ Tulassay Z, Herszényi L (April 2010). "Gastric mucosal defense and cytoprotection". Best Pract Res Clin Gastroenterol 24 (2): 99–108. doi:10.1016/j.bpg.2010.02.006. PMID 20227024.
- ↑ Wallace JL (September 1992). "Prostaglandins, NSAIDs, and cytoprotection". Gastroenterol. Clin. North Am. 21 (3): 631–41. doi:10.1016/S0889-8553(21)00052-2. PMID 1516961.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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