Medicine:Cytoprotection
Cytoprotection refers to the process by which certain pharmacological agents protect cells, particularly the gastric and intestinal mucosal cells, from injury caused by harmful substances, without inhibiting or neutralizing gastric acid.[1][2]
Gastric
A gastric cytoprotectant is any medication that combats ulcers not by reducing gastric acid but by increased mucus and bicarbonate secretion, enhancement of mucosal blood flow, cellular repair, and antioxidant activity.[3] Examples of gastric cytoprotective agents include prostaglandins which protect the stomach mucosa against injury by increasing gastric mucus secretion. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the synthesis of prostaglandins and thereby make the stomach more susceptible to injury.[4] Gastric cytoprotective drugs include carbenoxolone, deglycyrrhizinised liquorice, sucralfate (aluminium hydroxide and sulphated sucrose), misoprostol (a prostaglandin analogue), bismuth citrate and zinc L-carnosine.
References
- ↑ "MeSH Heading: Cytoprotection". Medical Subject Headings. United States National Library of Medicine. https://meshb.nlm.nih.gov/record/ui?ui=D019610.
- ↑ "Single-Cell Nanoencapsulation: Chemical Synthesis of Artificial Cell-in-Shell Spores" (in en). Chemical Reviews 125 (13): 6366–6396. 2025-05-22. doi:10.1021/acs.chemrev.4c00984. ISSN 0009-2665. PMID 40403226. https://pubs.acs.org/doi/10.1021/acs.chemrev.4c00984.
- ↑ ""Gastric cytoprotection" is still relevant". Journal of Gastroenterology and Hepatology 29 (Suppl 4): 124–32. December 2014. doi:10.1111/jgh.12735. PMID 25521744.
- ↑ "Prostaglandins, NSAIDs, and cytoprotection". Gastroenterology Clinics of North America 21 (3): 631–641. September 1992. doi:10.1016/S0889-8553(21)00052-2. PMID 1516961.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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